Southwest Illinois Vacations from $260

Book a Hotel + Flight or Car together to unlock savings

Photo by Southernmost Illinois Tourism Bureau
  • Plan, book, travel with confidence

  • Better together

    Save up to $2,000 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

Your Southwest Illinois Vacation

When it's time for your next epic adventure, our Southwest Illinois vacation packages are the answer. Culture and history are among the many things that make this destination such a special place. Begin your trip to Southwest Illinois with some time exploring O'Fallon visiting popular sights like O'Fallon Family Sports Park and FanDuel Sportsbook and Horse Racing. Marion is another city that lures travelers from all over. Lake of Egypt and Crab Orchard National Wildlife Refuge are two of the top places to see in this destination. From the moment you book your Southwest Illinois vacation to the second you come back home, Expedia will be with you each step of the way.

The Latest Southwest Illinois vacation packages

Price found within the past 48 hours. Click for updated prices.
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Riverport
$260
per person
Oct 8 - Oct 11
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
7.6/10 Good! (1,015 reviews)
There was nothing unique about the property. Would not recommend this place at all.we were on the 3rd floor to which our room had no working a.c in the living room area even tho it ran on 60 degrees. The pull out couch was not comfortable at all with very noticeable stains on the mattress. There was dirty dishes left in the dishwasher from the previous person.Key card to our room kept deactivated and you would have togo down multiple times to get it re active. We spent 5 days iheree becuse there was no refunds. And we had no other chOoice.ne of the ice machines worked in the entire hotel on all floors. They had 1 working elevators in the way back of the hotel for allfloors .So we had to carry the luggage up 3 flights of stairs. The hallway are not toclean.VERY!VERY!OUT DATEDALL PICTURES YOU SEE ON ANY ON LINE DOES NOT MATCH WHAT THE HOTEL IS. The breakfast was terrible boiled eggs and dried up cereal and 1 waffle maker.Not worth the price they charge for the rooms.The location is definitely not co n vient Definitely would not recommend.

Reviewed on Sep 4, 2026

Moonrise Hotel

Moonrise Hotel

Delmar Loop
Save 100% on your flight
$286
per person
Oct 16 - Oct 18
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
9/10 Wonderful! (2,031 reviews)
The hotel was continently located with free parking. The staff was very friendly and helpful. We will definitely staff again.

Reviewed on Sep 5, 2026

Residence Inn by Marriott St. Louis West County

Residence Inn by Marriott St. Louis West County

$1,003
per person
Nov 21 - Nov 28
found 21 hours ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
9.2/10 Wonderful! (265 reviews)
Ive stayed here before. Rooms are nice because they have a desk kitchen snd couch. Bed was not good. We stayed here because our ac went out. I called and confirmed pet friendly booked and paid for the room only to arrive and be told its $100 pet fee. Thats not fair or ok.

Reviewed on Sep 4, 2026

The Cheshire

The Cheshire

Save 100% on your flight
$465
per person
Oct 8 - Oct 11
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.8/10 Excellent! (1,014 reviews)
Residence Inn by Marriott St Louis Downtown

Residence Inn by Marriott St Louis Downtown

Midtown
$825
per person
Nov 21 - Nov 28
found 21 hours ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
7.8/10 Good! (1,002 reviews)
Don't see what you're looking for?
See all available trips from Columbus to Southwest Illinois
View all trips

Where to stay in Southwest Illinois

Find the best Southwest Illinois areas and neighborhoods for the activities you enjoy most. Learn more about Southwest Illinois
An aerial view of a city with a prominent river, a large bridge, and surrounding buildings.

Eastport

If you're spending some time in Eastport, Gateway Conference Center and Splash City Family Waterpark are top sights worth seeing.

A tall water tower with a red and white striped top, surrounded by trees and a clear blue sky.

Uptown

If you're spending some time in Uptown, Kruta Bakery and World's Largest Catsup Bottle are top sights worth seeing.

A river with a bridge, a city skyline, and a large industrial area.

Alorton

Alorton is well-liked for its restaurants. If you'd like to do some sightseeing in the greater East St. Louis area, you might plan a trip to Arsenal BG Ballpark or Gateway Arch.

Default Image

Mulberry Hills

While Mulberry Hills isn't home to many top sights, Gateway Conference Center and Stonewolf Golf Course are some notable places to visit nearby.

A large, historic building with arched windows and a prominent corner entrance.

Historic Downtown Collinsville

While Historic Downtown Collinsville isn't home to many top sights, Gateway Conference Center and Splash City Family Waterpark are some notable places to visit nearby.

Stay near popular Southwest Illinois attractions

Giant City State Park

9.2/10 (141 reviews)
Walk amid mystical woodland, admire geological wonders, go horseback riding and camp in the wilderness in the spectacular countryside of Southwest Illinois.
See properties

World Wide Technology Raceway

9.0/10 (2 reviews)
Catch an event at World Wide Technology Raceway during your trip to St. Louis. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.
See properties

O'Fallon Family Sports Park

8.6/10 (137 reviews)
Explore the great outdoors at O'Fallon Family Sports Park, a lovely green space in O'Fallon. Check out the shops and top-notch restaurants in this family-friendly area.
See properties

DuQuoin State Fairgrounds

8.2/10 (95 reviews)
Catch an event at DuQuoin State Fairgrounds during your trip to Du Quoin. Experience the area's festivals and live music.
See properties

Southwest Illinois Hotel Deals

Drury Inn & Suites St. Louis Fairview Heights

Drury Inn & Suites St. Louis Fairview Heights

12 Ludwig Dr Fairview Heights IL
Fully refundableReserve now, pay when you stay
$90 nightly
$102 total
Sep 20 - Sep 21
Total with taxes and fees
Drury Inn & Suites St. Louis Fairview Heights
Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon

145 North 44th Street  Mount Vernon IL
Fully refundableReserve now, pay when you stay
$109 nightly
$123 total
Sep 13 - Sep 14
Total with taxes and fees
9.8/10 Exceptional! (1,803 reviews)
"The sweetest staff & cleanest room you could imagine"

Reviewed on Sep 5, 2026

Drury Plaza Hotel Mt. Vernon
Super 8 by Wyndham O'Fallon

Super 8 by Wyndham O'Fallon

1100 Eastgate Dr O'Fallon IL
Fully refundableReserve now, pay when you stay
$54 nightly
$63 total
Sep 21 - Sep 22
Total with taxes and fees
Super 8 by Wyndham O'Fallon
See all 787 properties in Southwest Illinois
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Southwest Illinois Vacation Packages

Southwest Illinois Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Lambert-St. Louis Intl. Airport (STL)

More vacations you might like

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.