Southwest Illinois Vacations from $591
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to $2,000 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Your Southwest Illinois Vacation
When it's time for your next epic adventure, our Southwest Illinois vacation packages are the answer. Culture and history are among the many things that make this destination such a special place. Begin your trip to Southwest Illinois with some time exploring O'Fallon visiting popular sights like O'Fallon Family Sports Park and FanDuel Sportsbook and Horse Racing. Marion is another city that lures travelers from all over. Lake of Egypt and Crab Orchard National Wildlife Refuge are two of the top places to see in this destination. From the moment you book your Southwest Illinois vacation to the second you come back home, Expedia will be with you each step of the way.
The Latest Southwest Illinois vacation packages
Alhonna Resort LLC
Reviewed on Apr 30, 2026
Hilton Garden Inn Chesterfield
Reviewed on Apr 11, 2026
The Cheshire
Reviewed on Apr 18, 2026
Where to stay in Southwest Illinois
Eastport
If you're spending some time in Eastport, Gateway Conference Center and Splash City Family Waterpark are top sights worth seeing.
Discover the most popular places to visit in Southwest Illinois
Southern Illinois University
Take a campus tour or just explore the area of Southern Illinois University, during your trip to Carbondale. Check out the shops and top-notch restaurants in this family-friendly area.
Giant City State Park
Walk amid mystical woodland, admire geological wonders, go horseback riding and camp in the wilderness in the spectacular countryside of Southwest Illinois.
Ferne Clyffe State Park
You can take time to visit Ferne Clyffe State Park during your travels to Goreville. While you're in the area, wander around the parks.
Southwest Illinois Hotel Deals
Drury Inn & Suites St. Louis Fairview Heights
Friendly & Helpful staff. Great amenities: Breakfast & Evening gathering.
Reviewed on May 2, 2026
Super 8 by Wyndham O'Fallon
Drury Plaza Hotel Mt. Vernon
Very good
Reviewed on May 2, 2026
Find the Best Southwest Illinois Vacation Packages
Southwest Illinois Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | Lambert-St. Louis Intl. Airport (STL) |
More vacations you might like
Explore a world of travel with Expedia
- Addieville Hotels
- Motels in Addieville
- Hotels near Rainbow Ranch Petting Zoo
- Okawville Hotels
- B&B in Okawville
- Pet-Friendly Hotels in Okawville
- Motels in Okawville
- Apartments in Okawville
- Hotels near Washington County Courthouse
- Nashville Hotels
- Motels in Nashville
- B&B in Nashville
- 4 Star Hotels in Nashville
- Hotels with a Pool in Nashville
- Hotels near Nashville Memorial Park
- New Minden Hotels
- Oakdale Hotels
- Bartelso Hotels
- 3 Star Hotels in Damiansville
- Damiansville Hotels
- Germantown Hotels
- Saint Libory Hotels
- B&B in Saint Libory
- Albers Hotels
- Hoyleton Hotels
- New Baden Hotels
- B&B in New Baden
- Beckemeyer Hotels
- Breese Hotels
- Coulterville Hotels
- Motels in Breese
- Mascoutah Hotels
- La Quinta Inn & Suites Hotels in Mascoutah
- B&B in Mascoutah
- Drury Inn & Suites Hotels in Mascoutah
- Cabin Rentals in Mascoutah
- 3 Star Hotels in Mascoutah
- Flights to Okawville
- Flights from Okawville
- Flights to Nashville
- Flights from Nashville
- Flights from Venedy
- Flights from Oakdale
- Flights from Damiansville
- Flights from Saint Libory
- Flights from Albers
- Flights to Hoyleton
- Flights from New Baden
- Flights to Breese
- Flights to Coulterville
- Flights from Breese
- Flights to Mascoutah
- Denver to Mascoutah
- Flights from Mascoutah
- San Francisco to Mascoutah
- Orlando to Mascoutah
- Atlanta to Mascoutah
- Car rentals near Addieville
- Car rentals near Okawville
- Car rentals near Nashville
- Dollar Europe Rental Cars in Nashville
- Routes Rental Cars in Nashville
- Car rentals near New Minden
- Car rentals near Oakdale
- Car rentals near Bartelso
- Car rentals near Hoyleton
- Car rentals near New Baden
- Car rentals near Beckemeyer
- Car rentals near Breese
- Car rentals near Mascoutah
- Avis Rental Cars in Mascoutah
