Southwest Illinois Vacation Packages 2026 from $402

Photo by Southernmost Illinois Tourism Bureau

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Your Southwest Illinois Vacation

When it's time for your next epic adventure, our Southwest Illinois vacation packages are the answer. Culture and history are among the many things that make this destination such a special place. Begin your trip to Southwest Illinois with some time exploring O'Fallon visiting popular sights like O'Fallon Family Sports Park and FanDuel Sportsbook and Horse Racing. Marion is another city that lures travelers from all over. Lake of Egypt and Crab Orchard National Wildlife Refuge are two of the top places to see in this destination. From the moment you book your Southwest Illinois vacation to the second you come back home, Expedia will be with you each step of the way.

The Latest Southwest Illinois vacation packages

Price found within the past 48 hours. Click for updated prices.

The Knight Center at Washington University

$402

per person

Nov 7 - Nov 10

found 20 hours ago

Roundtrip flight included

Denver (DEN) to St. Louis (STL)

9.4/10 Exceptional! (685 reviews)

Very nice property. Great location. Easy parking. Rooms were pretty clean. The beds could use a refresh. The main issue was the temperature in the room was not comfortable at all. It was very hot. Neither the temperature nor the fan would adjust.

Reviewed on Sep 29, 2026

Hilton Pennywell St. Louis at the Arch

Downtown St. Louis

Save 100% on your flight

$560

per person

Nov 7 - Nov 10

found 11 hours ago

Roundtrip flight included

Denver (DEN) to St. Louis (STL)

8.8/10 Excellent! (1,137 reviews)

The Cheshire

$919

per person

Dec 23 - Dec 29

found 1 day ago

Roundtrip non-stop flight included

New York (NYC) to St. Louis (STL)

8.8/10 Excellent! (1,006 reviews)

It’s a unique (the rooms were named after authors 😊), and interesting hotel. The staff was friendly and helpful, the room was nice, and the breakfast was good. The only down side was the parking situation. We paid $10/day and many of the parking spots were filled by restaurant patrons (who parked for free). It was somewhat frustrating to drive around looking for a spot only to find out the only available spot was in lowest level of parking garage.

Reviewed on Sep 29, 2026

The Westin St. Louis

Downtown St. Louis

Save 100% on your flight

$411

per person

Nov 7 - Nov 10

found 11 hours ago

Roundtrip flight included

Denver (DEN) to St. Louis (STL)

8.6/10 Excellent! (1,008 reviews)

WorldMark Lake of the Ozarks

$464

per person

Nov 27 - Nov 29

found 15 hours ago

Roundtrip flight included

Minneapolis (MSP) to St. Louis (STL)

9.4/10 Exceptional! (428 reviews)

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Where to stay in Southwest Illinois

Find the best Southwest Illinois areas and neighborhoods for the activities you enjoy most. Learn more about Southwest Illinois

An aerial view of a city with a prominent river, a large bridge, and surrounding buildings.

Eastport

If you're spending some time in Eastport, Splash City Family Waterpark and Gateway Conference Center are top sights worth seeing.

Mulberry Hills

While Mulberry Hills isn't home to many top sights, World's Largest Catsup Bottle and Kruta Bakery are some notable places to visit nearby.

A tall water tower with a red and white striped top, surrounded by trees and a clear blue sky.

Uptown

If you're spending some time in Uptown, Kruta Bakery and World's Largest Catsup Bottle are top sights worth seeing.

A river with a bridge, a city skyline, and a large industrial area.

Alorton

Alorton is well-liked for its restaurants. If you'd like to do some sightseeing in the greater East St. Louis area, you might plan a trip to Frank Holten State Recreation Area or Arsenal BG Ballpark.

A large, historic building with arched windows and a prominent corner entrance.

Historic Downtown Collinsville

While Historic Downtown Collinsville isn't home to many top sights, World's Largest Catsup Bottle and Kruta Bakery are some notable places to visit nearby.

Stay near popular Southwest Illinois attractions

Giant City State Park

9.2/10 (141 reviews)

Walk amid mystical woodland, admire geological wonders, go horseback riding and camp in the wilderness in the spectacular countryside of Southwest Illinois.

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World Wide Technology Raceway

9.0/10 (2 reviews)

Catch an event at World Wide Technology Raceway during your trip to St. Louis. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.

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O'Fallon Family Sports Park

8.6/10 (137 reviews)

Explore the great outdoors at O'Fallon Family Sports Park, a lovely green space in O'Fallon. Check out the shops and top-notch restaurants in this family-friendly area.

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DuQuoin State Fairgrounds

8.2/10 (95 reviews)

Catch an event at DuQuoin State Fairgrounds during your trip to Du Quoin. Experience the area's festivals and live music.

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Southwest Illinois Hotel Deals

Drury Inn & Suites St. Louis Fairview Heights

12 Ludwig Dr Fairview Heights IL

Fully refundableReserve now, pay when you stay

$113 nightly

$128 total

Oct 5 - Oct 6

Total with taxes and fees

Drury Inn & Suites Marion

2706 W DeYoung St Marion IL

Fully refundableReserve now, pay when you stay

$94 nightly

$113 total

Oct 18 - Oct 19

Total with taxes and fees

Drury Plaza Hotel Mt. Vernon

145 North 44th Street Mount Vernon IL

Fully refundableReserve now, pay when you stay

$111 nightly

$125 total

Oct 11 - Oct 12

Total with taxes and fees

9.8/10 Exceptional! (1,826 reviews)

"Everything was great clean staff was great food was great can’t wait to go back"

Reviewed on Sep 29, 2026

See all 796 properties in Southwest Illinois

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.