Southwest Illinois Vacation Packages 2026 from $307

Photo by Southernmost Illinois Tourism Bureau

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Your Southwest Illinois Vacation

When it's time for your next epic adventure, our Southwest Illinois vacation packages are the answer. Culture and history are among the many things that make this destination such a special place. Begin your trip to Southwest Illinois with some time exploring O'Fallon visiting popular sights like O'Fallon Family Sports Park and FanDuel Sportsbook and Horse Racing. Marion is another city that lures travelers from all over. Lake of Egypt and Crab Orchard National Wildlife Refuge are two of the top places to see in this destination. From the moment you book your Southwest Illinois vacation to the second you come back home, Expedia will be with you each step of the way.

The Latest Southwest Illinois vacation packages

Price found within the past 48 hours. Click for updated prices.

Moonrise Hotel

Delmar Loop

Save 100% on your flight

$307

per person

Nov 6 - Nov 9

found 15 hours ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

9/10 Wonderful! (2,016 reviews)

The only thing that I may have negative to say is the restaurant is very pricey but there are plenty other places around to eat of course. This hotel was absolutely phenomenal for my kids and I. It was the perfect trip hands down. Plan to visit again

Reviewed on Sep 20, 2026

The Wildwood Hotel

Save 100% on your flight

$645

per person

Nov 23 - Nov 30

found 1 day ago

Roundtrip flight included

Houston (HOU) to St. Louis (STL)

9.2/10 Wonderful! (1,657 reviews)

No room, reset or towels or trash pickup when staying two nights. 20mi from St Louis

Reviewed on Sep 19, 2026

The Cheshire

Save 100% on your flight

$379

per person

Nov 6 - Nov 9

found 17 hours ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

8.8/10 Excellent! (1,004 reviews)

Charming and quaint alternative to a Holiday Inn. It was renovated 10-15 years ago but not much care since then. The pool was allegedly open still (mid September) but when we looked out to go use it, there was debris in it and it wasn’t very inviting. The price was affordable and it was pet friendly, I only wish we could have experienced it during its heyday years ago when it was properly maintained and cleaned.

Reviewed on Sep 17, 2026

Ameristar Casino Resort and Spa

Save 100% on your flight

$836

per person

Nov 3 - Nov 10

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

8.6/10 Excellent! (1,033 reviews)

The Knight Center at Washington University

Save 100% on your flight

$310

per person

Nov 6 - Nov 9

found 17 hours ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

9.4/10 Exceptional! (668 reviews)

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Where to stay in Southwest Illinois

Find the best Southwest Illinois areas and neighborhoods for the activities you enjoy most. Learn more about Southwest Illinois

An aerial view of a city with a prominent river, a large bridge, and surrounding buildings.

Eastport

If you're spending some time in Eastport, Gateway Conference Center and Splash City Family Waterpark are top sights worth seeing.

A tall water tower with a red and white striped top, surrounded by trees and a clear blue sky.

Uptown

If you're spending some time in Uptown, World's Largest Catsup Bottle and Kruta Bakery are top sights worth seeing.

Mulberry Hills

While Mulberry Hills isn't home to many top sights, World's Largest Catsup Bottle and Gateway Conference Center are some notable places to visit nearby.

A river with a bridge, a city skyline, and a large industrial area.

Alorton

Alorton is well-liked for its restaurants. If you'd like to do some sightseeing in the greater East St. Louis area, you might plan a trip to Frank Holten State Recreation Area or Arsenal BG Ballpark.

A large, historic building with arched windows and a prominent corner entrance.

Historic Downtown Collinsville

While Historic Downtown Collinsville isn't home to many top sights, World's Largest Catsup Bottle and Gateway Conference Center are some notable places to visit nearby.

Stay near popular Southwest Illinois attractions

Giant City State Park

9.2/10 (141 reviews)

Walk amid mystical woodland, admire geological wonders, go horseback riding and camp in the wilderness in the spectacular countryside of Southwest Illinois.

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World Wide Technology Raceway

9.0/10 (2 reviews)

Catch an event at World Wide Technology Raceway during your trip to St. Louis. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.

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O'Fallon Family Sports Park

8.6/10 (137 reviews)

Explore the great outdoors at O'Fallon Family Sports Park, a lovely green space in O'Fallon. Check out the shops and top-notch restaurants in this family-friendly area.

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DuQuoin State Fairgrounds

8.2/10 (95 reviews)

Catch an event at DuQuoin State Fairgrounds during your trip to Du Quoin. Experience the area's festivals and live music.

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Southwest Illinois Hotel Deals

Drury Inn & Suites St. Louis Fairview Heights

12 Ludwig Dr Fairview Heights IL

Fully refundableReserve now, pay when you stay

$93 nightly

$105 total

Sep 28 - Sep 29

Total with taxes and fees

9.2/10 Wonderful! (1,022 reviews)

"Clean rooms awesome breakfast and staff"

Reviewed on Sep 17, 2026

Drury Inn & Suites Marion

2706 W DeYoung St Marion IL

Fully refundableReserve now, pay when you stay

$105 nightly

$126 total

Oct 11 - Oct 12

Total with taxes and fees

9.4/10 Exceptional! (1,002 reviews)

"Loved the evening happy hour after a long day of driving"

Reviewed on Sep 20, 2026

Drury Plaza Hotel Mt. Vernon

145 North 44th Street Mount Vernon IL

Fully refundableReserve now, pay when you stay

$111 nightly

$125 total

Sep 27 - Sep 28

Total with taxes and fees

See all 790 properties in Southwest Illinois

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.