Southwest Illinois Vacation Packages 2026 from $532

Photo by Southernmost Illinois Tourism Bureau

Your Southwest Illinois Vacation

When it's time for your next epic adventure, our Southwest Illinois vacation packages are the answer. Culture and history are among the many things that make this destination such a special place. Begin your trip to Southwest Illinois with some time exploring O'Fallon visiting popular sights like O'Fallon Family Sports Park and FanDuel Sportsbook and Horse Racing. Marion is another city that lures travelers from all over. Lake of Egypt and Crab Orchard National Wildlife Refuge are two of the top places to see in this destination. From the moment you book your Southwest Illinois vacation to the second you come back home, Expedia will be with you each step of the way.

The Latest Southwest Illinois vacation packages

Price found within the past 48 hours. Click for updated prices.

The Wildwood Hotel

$532

per person

Dec 3 - Dec 7

found 1 day ago

Roundtrip flight included

Boston (BOS) to St. Louis (STL)

9.2/10 Wonderful! (1,672 reviews)

The Cheshire

$604

per person

Dec 11 - Dec 14

found 1 day ago

Roundtrip flight included

Boston (BOS) to St. Louis (STL)

8.8/10 Excellent! (1,006 reviews)

Moonrise Hotel

Delmar Loop

$593

per person

Dec 11 - Dec 14

found 1 day ago

Roundtrip flight included

Boston (BOS) to St. Louis (STL)

9/10 Wonderful! (2,026 reviews)

Always enjoy my stay here. The shower was not made for heavy set people. I could barely get through the sliding glass door

Reviewed on Sep 30, 2026

Ameristar Casino Resort and Spa

$753

per person

Dec 3 - Dec 7

found 1 day ago

Roundtrip flight included

Boston (BOS) to St. Louis (STL)

8.6/10 Excellent! (1,062 reviews)

The Knight Center at Washington University

$543

per person

Dec 11 - Dec 14

found 1 day ago

Roundtrip flight included

Boston (BOS) to St. Louis (STL)

9.4/10 Exceptional! (685 reviews)

Very nice property. Great location. Easy parking. Rooms were pretty clean. The beds could use a refresh. The main issue was the temperature in the room was not comfortable at all. It was very hot. Neither the temperature nor the fan would adjust.

Reviewed on Sep 29, 2026

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Where to stay in Southwest Illinois

Find the best Southwest Illinois areas and neighborhoods for the activities you enjoy most. Learn more about Southwest Illinois

An aerial view of a city with a prominent river, a large bridge, and surrounding buildings.

Eastport

If you're spending some time in Eastport, Splash City Family Waterpark and Gateway Conference Center are top sights worth seeing.

Mulberry Hills

While Mulberry Hills isn't home to many top sights, World's Largest Catsup Bottle and Kruta Bakery are some notable places to visit nearby.

A tall water tower with a red and white striped top, surrounded by trees and a clear blue sky.

Uptown

If you're spending some time in Uptown, Kruta Bakery and World's Largest Catsup Bottle are top sights worth seeing.

A river with a bridge, a city skyline, and a large industrial area.

Alorton

Alorton is well-liked for its restaurants. If you'd like to do some sightseeing in the greater East St. Louis area, you might plan a trip to Frank Holten State Recreation Area or Arsenal BG Ballpark.

A large, historic building with arched windows and a prominent corner entrance.

Historic Downtown Collinsville

While Historic Downtown Collinsville isn't home to many top sights, World's Largest Catsup Bottle and Kruta Bakery are some notable places to visit nearby.

Stay near popular Southwest Illinois attractions

Giant City State Park

9.2/10 (141 reviews)

Walk amid mystical woodland, admire geological wonders, go horseback riding and camp in the wilderness in the spectacular countryside of Southwest Illinois.

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World Wide Technology Raceway

9.0/10 (2 reviews)

Catch an event at World Wide Technology Raceway during your trip to St. Louis. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.

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O'Fallon Family Sports Park

8.6/10 (137 reviews)

Explore the great outdoors at O'Fallon Family Sports Park, a lovely green space in O'Fallon. Check out the shops and top-notch restaurants in this family-friendly area.

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DuQuoin State Fairgrounds

8.2/10 (95 reviews)

Catch an event at DuQuoin State Fairgrounds during your trip to Du Quoin. Experience the area's festivals and live music.

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Southwest Illinois Hotel Deals

Drury Inn & Suites St. Louis Fairview Heights

12 Ludwig Dr Fairview Heights IL

Fully refundableReserve now, pay when you stay

$90 nightly

$102 total

Nov 1 - Nov 2

Total with taxes and fees

9.2/10 Wonderful! (1,035 reviews)

"Clean hotel. We enjoyed our stay. Nice pool and hot tub, decent hotel gym."

Reviewed on Oct 1, 2026

Drury Inn & Suites Marion

2706 W DeYoung St Marion IL

Fully refundableReserve now, pay when you stay

$65 nightly

$78 total

Nov 1 - Nov 2

Total with taxes and fees

Drury Plaza Hotel Mt. Vernon

145 North 44th Street Mount Vernon IL

Fully refundableReserve now, pay when you stay

$111 nightly

$125 total

Oct 11 - Oct 12

Total with taxes and fees

See all 796 properties in Southwest Illinois

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.