Southwest Illinois Vacations from $305
Book a Hotel + Flight or Car together to unlock savings
Your Southwest Illinois Vacation
When it's time for your next epic adventure, our Southwest Illinois vacation packages are the answer. Culture and history are among the many things that make this destination such a special place. Begin your trip to Southwest Illinois with some time exploring O'Fallon visiting popular sights like O'Fallon Family Sports Park and FanDuel Sportsbook and Horse Racing. Marion is another city that lures travelers from all over. Lake of Egypt and Crab Orchard National Wildlife Refuge are two of the top places to see in this destination. From the moment you book your Southwest Illinois vacation to the second you come back home, Expedia will be with you each step of the way.
The Latest Southwest Illinois vacation packages
HoteLumiere at the Arch - A Caesars Rewards Destination
Reviewed on Oct 29, 2025
Hilton Garden Inn St. Louis/O'Fallon MO
Reviewed on Oct 20, 2025
Sheraton Westport Plaza Hotel St. Louis
Reviewed on Oct 27, 2025
Hilton Garden Inn Chesterfield
Reviewed on Oct 26, 2025
Where to stay in Southwest Illinois
Eastport
If you're spending some time in Eastport, Gateway Conference Center and Splash City Family Waterpark are top sights worth seeing.
Discover the most popular places to visit in Southwest Illinois
Southern Illinois University
Take a campus tour or just explore the area of Southern Illinois University, during your trip to Carbondale. Check out the shops and top-notch restaurants in this family-friendly area.
Giant City State Park
Walk amid mystical woodland, admire geological wonders, go horseback riding and camp in the wilderness in the spectacular countryside of Southwest Illinois.
Ferne Clyffe State Park
You can take time to visit Ferne Clyffe State Park during your travels to Goreville. While you're in the area, wander around the parks.
Southwest Illinois Hotel Deals
Drury Plaza Hotel Mt. Vernon
Another awesome Drury!!!
Reviewed on Nov 18, 2025
Super 8 by Wyndham O'Fallon
The room was very comfortable with a good layout. The mattress was comfortable. The climate control was easy to operate and efficient. Every staff member we met was friendly.
Reviewed on Nov 9, 2025
Quality Inn & Suites near St. Louis and I-255
Great
Reviewed on Nov 17, 2025
Find the Best Southwest Illinois Vacation Packages
Southwest Illinois Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | Lambert-St. Louis Intl. Airport (STL) |
More vacations you might like
Explore a world of travel with Expedia
- Addieville Hotels
- Motels in Addieville
- Hotels near Rainbow Ranch Petting Zoo
- Okawville Hotels
- B&B in Okawville
- Pet-friendly Hotels in Okawville
- Motels in Okawville
- Apartments in Okawville
- Hotels near Washington County Courthouse
- Nashville Hotels
- Motels in Nashville
- B&B in Nashville
- 4 Star Hotels in Nashville
- Hotels with a Pool in Nashville
- Hotels near Nashville Memorial Park
- New Minden Hotels
- Oakdale Hotels
- Bartelso Hotels
- 3 Star Hotels in Damiansville
- Damiansville Hotels
- Germantown Hotels
- Saint Libory Hotels
- B&B in Saint Libory
- Albers Hotels
- Hoyleton Hotels
- New Baden Hotels
- B&B in New Baden
- Beckemeyer Hotels
- Breese Hotels
- Coulterville Hotels
- Motels in Breese
- Mascoutah Hotels
- La Quinta Inn & Suites Hotels in Mascoutah
- B&B in Mascoutah
- Drury Inn & Suites Hotels in Mascoutah
- Cabin Rentals in Mascoutah
- 3 Star Hotels in Mascoutah
- Flights to Okawville
- Flights from Okawville
- Flights to Nashville
- Flights from Nashville
- Flights from Venedy
- Flights from Oakdale
- Flights from Damiansville
- Flights from Saint Libory
- Flights from Albers
- Flights to Hoyleton
- Flights from New Baden
- Flights to Breese
- Flights to Coulterville
- Flights from Breese
- Flights to Mascoutah
- Flights from Denver to Mascoutah
- Flights from Mascoutah
- Flights from San Francisco to Mascoutah
- Flights from Orlando to Mascoutah
- Flights from Tampa to Mascoutah
- Flights from London to Mascoutah
- Flights from Newport News to Mascoutah
- Flights from Galesburg to Mascoutah
- Flights from Springfield to Mascoutah
- Flights from Quincy to Mascoutah
- Flights from Des Moines to Mascoutah
- Flights from Atlanta to Mascoutah
- Flights from Ada to Mascoutah
- Car rentals near Addieville
- Car rentals near Okawville
- Car rentals near Nashville
- Dollar Europe Rental Cars in Nashville
- Routes Rental Cars in Nashville
- Car rentals near New Minden
- Car rentals near Oakdale
- Car rentals near Bartelso
- Car rentals near Hoyleton
- Car rentals near New Baden
- Car rentals near Beckemeyer
- Car rentals near Breese
- Car rentals near Mascoutah
- Avis Rental Cars in Mascoutah